Advances in Cell Mechanics by Ignacio Romero, Juan J. Arribas (auth.), Prof. Shaofan Li,

By Ignacio Romero, Juan J. Arribas (auth.), Prof. Shaofan Li, Prof. Bohua Sun (eds.)

"Advances in phone Mechanics" offers the newest advancements in cellphone mechanics and biophysics, typically concentrating on interdisciplinary study in telephone biology and the biophysics of cells. additionally, a different characteristic of the e-book is its emphasis at the molecular and complicated continuum modeling and simulations of the cells. it can be the 1st paintings that brings rigorous and quantitative medical research and cutting-edge simulation expertise into phone biology research.

The e-book is meant for researchers and graduate scholars operating within the fields of molecular telephone biology, bio-engineering and bio-mechanics, delicate topic physics, computational mechanics, bio-chemistry and bio-medicine.

All members are major students of their respective fields. Dr. Shaofan Li is a professor and knowledgeable for computational mechanics on the collage of California-Berkeley, united states; Dr. Bohua solar is a professor at Cape Peninsula collage of expertise, South Africa.

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In this work we have proposed a mechanical and computational model of cell ensembles. The simplifications alluded to above result in tractable equations which can be solved using techniques of nonlinear finite elements. The proposed framework includes nonlinear homogenized cell mechanics providing a simple model for deformation and growth. To describe cell interactions, a penalty formulation is used to account for cell-to-cell contact forces, and an effective adhesion model replaces membrane adherence.

154: 135-156, 2000. [27] Hughes T J R, Talor R, Sackman J, et al. A finite element method for a class of contact-impact problem. Computer Methods in Applied Mechanics and Engineering, 8: 249-276, 1976. [28] Li S, Qian D, Liu W K and Belytschko T. A meshfree contact-detection algorithm. Computer Methods in Applied Mechanics and Engineering, 190: 3271-3292, 2001. [29] Sauer R A, and Li S F. A contact mechanics model for quasi-continua. International Journal for Numerical Methods in Engineering, 71: 931-962, 2007.

Developing soft matter physics models for stem cells may help us understand the biomechanical and biochemical behavior of cells. It has been shown in this paper that the soft matter approach can offer explanations regarding the interaction between stem cells and its mechanical niche. In some cases, the soft matter physics model has even shown a predictive power. It is the authors’ opinion that by combining the soft matter model with a molecular simulation, we may be able to achieve qualitative prediction of cell behavior while corroborating with experimental observation.

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