Aging and Age Related Ocular Diseases (Ophthalmologica, 1) by E. Lütjen-Drecoll

By E. Lütjen-Drecoll

The phenomenon of getting older is characterised via a number of degenerative adjustments, which differentially impact the hugely really expert constructions in the eye, comparable to the simply mobile lens, the brain-derived retina and the connective tissue of the uvea and sclera. as a result, the attention can function an outstanding version method to check age-related degenerative illnesses. an summary article offers with the molecular biology of alpha-B-crystallin, and unique articles supply additional perception into the distribution and attainable practical importance of nonlenticular alpha-B-crystallin. Retinal transplantation stories which may finally bring about remedy for tapetoretinal degeneration and age-related macular degeneration are mentioned. extra, elements that impression the advance of the retinal tissues are investigated. And one other assessment examines cells of the deep lens fibers. This certain factor is an in-depth resource of data to ophthalmologists in learn and perform.

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Electrical Characteristics of Ion Channels and Transporters In a series of experiments, we tried to determine what ionic channels and transporters are involved in regulating the membrane potential of trabecular meshwork cells and what pharmacological agents are able to modify this parameter. Potassium Channels. We have already indicated that potassium conductance is the major factor contributing to the resting membrane voltage of trabecular meshwork cells. Accordingly, an elevation of external potassium to 135 mmol/l depolarized both human and bovine trabecular meshwork cells by preventing efflux of potassium [14, 119, 120].

J Neurosci Res 1990; 25:300–311. 34 Oblinger MM, Singh LD: Reactive astrocytes in neonate brain upregulate intermediate filament gene expression in response to axonal injury. Int J Dev Neurosci 1993;11:149–156. 35 Varela HJ, Hernandez MR: Astrocyte responses in human optic nerve head with primary open-angle glaucoma. J Glaucoma 1997;6: 303–313. 36 Hernandez MR, Pena JDO: The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol 1997;115:389–395. Furuyoshi/Furuyoshi/May/Hayreh/Alm/ Lütjen-Drecoll Ophthalmologica 2000;214:33–53 Regulation of Trabecular Meshwork Contractility Friederike Stumpff Michael Wiederholt Institut für Klinische Physiologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Deutschland Key Words Glaucoma W Trabecular meshwork W Smooth muscle W Aqueous humor outflow W Contractility Abstract Ample evidence supports the theory that trabecular meshwork possesses smooth-muscle-like properties.

The intima of single vessels was thickened due to an increase in connective tissue in the intimal layer, and some smooth muscle cells had invaded the inner elastic membrane. Correlation of Morphological Changes with IOP In the rhesus monkeys, there was no correlation between the severity of optic nerve damage and either last IOP measurement, IOP peaks or mean IOP. In cynomolgus monkeys with increased IOP for 4 years, loss of nerve fibers accompanied by loss of oligodendrocytes and loss of capillaries was more pronounced than in the rhesus monkey eyes with glaucoma for 14–43 months.

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