By Vincent J. Cristofalo PhD
This quantity provides a transparent, concise evaluate of the present kingdom of information concerning the biology of getting older √± serving as either a useful graduate-level textual content and a key reference for practising pros. Over a dozen exceptional participants probe the most recent advancements in our wisdom of why humans age and the way the method works. those authoritative chapters will not be simply written for biologists √± yet for gerontologists regularly. Marks the 10th anniversary of the yearly evaluation of Gerontology and Geriatrics.
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Additional resources for Annual Review of Gerontology and Geriatrics, Volume 10, 1990: Biology of Aging
Review lecturer on senescence: I. The causes of aging. Proceedings of the Royal Society of London, (B), 157, 115. Masoro, E. J. (1985). Metabolism. In C. E. Finch, & E. L. ), Handbook of the Biology of Aging (p. 540). New York: Van Nostrand Reinhold. Medawar, P. B. (1952). An unsolved problem of biology. London: H. K. Lewis. , Holliday, R. (1981). Increased error frequency of DNA polymerases from senescent human fibroblasts. Journal of Molecular Biology, 146, 55. Oliver, C. , et al. (1985). Age-related alterations of enzymes may involve mixedfunction oxidation reactions.
1. Summary of 25 Cases of Progeria. 5 54 No. Sibs 1 2 2 3 3 6 2 1 1 13 1 1 1 3 2 1 1 3 2 2 1 1 0 0 1 'identical twins Z\F-M; father's age minus mother's age. , familial hypercholesterolemia) in which half the normal level of the gene product can lead to a disease. Several genetic considerations suggest progeria is most likely a sporadic dominant mutation. , first-cousin marriages) are expected in rare recessive diseases. High consanguinity is not seen in progeria, and none of the patients I have examined came from consanguineous 28 W.
This has allowed the children and families to meet each other and to share common experiences. Genetic counseling has been given to the families regarding this rare condition. These meetings have been a unique and valuable experience for all concerned. Genetics of Progeria A consideration of the mode of inheritance in progeria is important for genetic counseling and may help to understand the nature of the underlying mutation. Recessive diseases often appear to be due to enzymatic deficiencies that lead to metabolic abnormalities.