Biological Basis of Geriatric Oncology by Lodovico Balducci, Martine Extermann

By Lodovico Balducci, Martine Extermann

Biological foundation of Geriatric Oncology highlights examine concerns which are particular to geriatric oncology within the box of carcinogenesis and melanoma prevention and therapy, according to the biologic interactions of melanoma and age. It illustrates the good thing about the foundations of geriatrics within the administration of melanoma within the older individual.

This quantity presents a body of reference for practicioners of any specialties concerned with the administration of older sufferers and for oncologists concerned with the administration of melanoma of older contributors. it's a resource for uncomplicated and scientific scientists exploring the interactions and rising details of melanoma and aging.

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1991; 68:2496-2501 Dilman VM: Development, aging, and disease. A new rationale for and intervention strategy. Chur: Harwood Acad Publ Switzerland, 1994 BIOLOGICAL INTERACTIONS 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 43 Simpson AJG: A natural somatic mutation frequency and human carcinogenesis. Adv Cancer Res 1993;71:209-240 Campisi J: Cancer and ageing: rival demons? Nature Rev Cancer 2003;3:339-349 DePinho RA: The age of cancer. Nature 2000; 408:248-254 von Wangenheim KH; Peterson HP: Control of cell proliferation by progress in differentiation: clues to mechanisms of aging, cancer causation and therapy.

Immunological analysis revealed a smaller population and lower activity of splenic natural killer cells in homozygous tg/tg rats. These results BIOLOGICAL INTERACTIONS 37 provided evidence that an optimal level of the GH-IGF-1 axis function needs for longevity in mammals. Recently it was shown that the incidence of mutations in insulin regulatory region (IRE) of APO C-III T-455 C directly correlates with longevity in humans. This is the first evidence showing that mutation located downstream to daf-16 in insulin signal transduction system is associated with longevity 117.

Biogerontoloy 2003; 4: 303-313 82. Harman DH: Free-radical theory of aging: increasing the functional life span. Ann NY Acad Sci 1994; 717:257-266 83. Reiter RJ: Reactive oxygen species, DNA damage, and carcinogenesis: intervention with melatonin. In Bartsch C; Bartsch H; Blask DE; Cardinali DP; Hrushesky WJM; Mecke D (eds): The Pineal Gland and Cancer. Berlin: Springer-Verlag: 2001:442-455 84. Coller HA; Khrapko K; Bodyak ND et al: High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection.

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